CLINICAL EVIDENCE
Evidence-Based Results
Junera's clinical foundation in subdermal laser tissue remodeling spans 15+ peer-reviewed publications, including a systematic review of 31 studies — providing physicians with the evidence they need to recommend treatment with confidence.
15+
PEER-REVIEWED PUBLICATIONS
534
LARGEST STUDY (PROCEDURES)
Reynaud et al., 2009
48.75%
% DERMIS DENSITY INCREASE
Nilforoushzadeh et al., 2023
53.78%
% WRINKLE VOLUME DECREASE
Nilforoushzadeh et al., 2023
COMPLETE EVIDENCE LIBRARY
Peer-Reviewed Research
Click any study with a DOI to access the full publication. Studies marked with PMC IDs are freely available through PubMed Central.
Reynaud JP, Skibinski M, Wassmer B, Rochon P, Mordon S
Aesthetic Plastic Surgery (2009) · Cited by 106
Key Finding: 980nm wavelength effective for lipolysis across 534 procedures with consistent results and 80% patient satisfaction
Bollero D, Orlando P, Fioramonti P, Lupo L, Dessy LA
Laser Therapy (2014)
Key Finding: 20 J/cm² optimal for neocollagenesis; 40 J/cm² causes thermal damage — establishes safe energy parameters
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Skin Research and Technology (2023) · Cited by 21
Key Finding: 43.75% dermis density increase, 26.78% wrinkle volume reduction, high patient satisfaction
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Skin Research and Technology (2024) · Cited by 4
Key Finding: 48.75% dermis density increase, 53.78% wrinkle volume decrease, 80% patient satisfaction
Nilforoushzadeh MA, Heidari-Kharaji M, Behrangi E, et al.
Lasers in Medical Science (2022) · Cited by 22
Key Finding: 90% improvement in eye bag appearance, increased dermis and epidermis thickness, 0 complications
Nilforoushzadeh MA, Heidari-Kharaji M, Behrangi E, et al.
Journal of Cosmetic Dermatology (2022) · Cited by 26
Key Finding: 90% patient improvement in upper eyelid and eyebrow ptosis, increased skin thickness, density, and elasticity
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Lasers in Medical Science (2022) · Cited by 29
Key Finding: ~90% patient and physician satisfaction, no serious adverse events for jowl fat reduction
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Journal of Cosmetic Dermatology (2022) · Cited by 14
Key Finding: Significant fat reduction and skin tightening in submental area, high patient satisfaction
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Journal of Cosmetic Dermatology (2023) · Cited by 8
Key Finding: Significant improvement in arm skin laxity with high patient satisfaction
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Lasers in Medical Science (2023) · Cited by 6
Key Finding: Effective abdominal skin tightening with measurable improvement in skin density
Nilforoushzadeh MA, Heidari-Kharaji M, Fakhim T, et al.
Skin Research and Technology (2023) · Cited by 5
Key Finding: Significant thigh skin tightening with improved dermis density
de Moura LB, et al.
Lasers in Medical Science (2023) · Cited by 3
Key Finding: Novel application showing improvement in rosacea symptoms
Nilforoushzadeh MA, et al.
Journal of Cosmetic Dermatology (2024) · Cited by 2
Key Finding: Effective buttock skin tightening with high satisfaction
Nilforoushzadeh MA, et al.
Lasers in Medical Science (2024) · Cited by 8
Key Finding: Systematic review confirming no serious adverse events reported across 31 studies with consistent efficacy
Suárez GA, Sanabria B, González N
Cirugía Plástica Ibero-Latinoamericana (2022) · Cited by 5
Key Finding: Significant dermis thickness/density increase at 90 days, 33.3% improved Merz grade for facial wrinkles
de Moura LB, Odo MEY, Odo LM, et al.
Journal of Cosmetic and Laser Therapy (2023) · Cited by 6
Key Finding: 4+ years of clinical experience confirming long-term efficacy and safety of subdermal laser for body contouring
de Moura LB, et al.
Lasers in Medical Science (2023) · Cited by 4
Key Finding: Dual-wavelength approach combining 980nm vascular targeting with 1470nm tissue remodeling shows promising results for rosacea treatment
Nilforoushzadeh MA, Heidari-Kharaji M, et al.
Journal of Cosmetic Dermatology (2023) · Cited by 7
Key Finding: Combined subdermal laser and nanofat grafting achieves ~90% improvement in acne scar appearance
Need the full evidence package? Through Onyxa On Demand, providers can access a comprehensive clinical evidence summary including all study PDFs, treatment protocols, and outcome data via the Junera Knowledge Base — or contact your dedicated Concierge at [email protected].
ONYXA ON DEMAND
Access the Full Evidence Library
Through Onyxa On Demand, providers access the complete clinical evidence package, treatment protocols, and downloadable study summaries via the Junera Knowledge Base — with your dedicated Concierge available for case-specific guidance.